Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 220 time(s) and present in 194 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
ITAItaly Sardinia pop30.2040100See
FRAFrance West29.00.1573100See
ESPSpain Gipuzkoa Basque0.1360100See
ITAItaly North pop 326.70.133097See
NIRIreland Northern23.90.12701000See
IRLIreland South24.00.1240250See
INDIndia Khandesh Region Pawra0.120050See
ESPSpain Catalonia Girona0.115088See
ESPSpain (Catalunya, Navarra, Extremadura, Aaragón, Cantabria,20.00.10604335See
GBRUnited Kingdom pop 319.70.1060604See
ESPSpain Andalusia0.104099See
CHESwitzerland Geneva pop 20.10251267See
ENGEngland North West19.50.1020298See
DEUGermany DKMS - United Kingdom minority0.09791043See
USAUSA Caucasian pop 20.0960265See
FRAFrance Corsica Island0.0950100See
CHESwitzerland Luzern0.09421553See
ESPSpain Majorca and Minorca0.094090See
USAUSA San Antonio Caucasian0.0939222See
USAUSA NMDP European Caucasian0.09391242890See
ESPSpain Sevilla18.00.0935278See
CHESwitzerland St Gallen0.09342113See
DEUGermany DKMS - Spain minority0.09031107See
AUSAustralia New South Wales Caucasian0.0890134See
CHESwitzerland Bern0.08883545See
USAUSA Philadelphia Caucasian17.30.0870141See
CHESwitzerland Zurich0.08694875See
USAUSA Caucasian pop 40.08511070See
FRAFrance Southeast16.20.0840130See
ITAItaly Bergamo14.90.0840101See
USAUSA Caucasian Bethesda15.90.0800307See
CHESwitzerland Lausanne0.0798993See
MARMorocco Nador Metalsa pop 20.079073See
USAUSA NMDP American Indian South or Central America0.07905926See
DEUGermany DKMS - France minority0.07661406See
USAUSA NMDP North American Amerindian0.076135791See
USAUSA San Francisco Caucasian0.0760220See
CHESwitzerland Aargau-Solothurn0.07561838See
CHESwitzerland Lugano0.07341169See
CHESwitzerland Basel0.07331888See
DEUGermany pop 60.07338862See
NLDNetherlands Leiden0.07101305See
DEUGermany DKMS - Netherlands minority0.07061374See
DEUGermany DKMS - German donors0.07023456066See
CHESwitzerland Sion0.0693832See
CHESwitzerland Graubunden0.0670759See
CZECzech Republic0.0660106See
DEUGermany Essen12.10.0640174See
DEUGermany DKMS - Portugal minority0.06401176See
DEUGermany pop 80.063839689See
USAUSA NMDP Alaska Native or Aleut0.06201376See
USAUSA Hispanic0.0620234See
PRTAzores Terceira Island0.0620130See
PRTPortugal Azores Terceira Island12.30.0614130See
PRTPortugal Center pop 20.0610562See
BRABrazil Mixed0.0610108See
DEUGermany DKMS - Italy minority0.05931159See
USAUSA NMDP Hispanic South or Central American0.0579146714See
USAUSA NMDP Mexican or Chicano0.0575261235See
ITAItaly pop 50.0570975See
USAUSA Eastern European0.0560558See
USAUSA NMDP Caribean Hispanic0.0556115374See
DEUGermany DKMS - Romania minority0.05511234See
JORJordan Amman0.0550146See
USAUSA San Diego10.60.0540496See
DEUGermany DKMS - Austria minority0.05271698See
COLColombia Bogotá Cord Blood9.80.05061463See
CZECzech Republic NMDR0.04745099See
RUSRussia Karelia0.04741075See
NLDNetherlands UMCU9.40.046964See
USAUSA Hispanic pop 20.04651999See
CHLChile Santiago Mixed9.00.046070See
DEUGermany DKMS - Croatia minority0.04582057See
USAUSA NMDP Middle Eastern or North Coast of Africa0.045270890See
ITAItaly North0.0450277See
NICNicaragua Managua8.80.0440339See
POLPoland DKMS0.043220653See
UGAUganda Kampala0.0400161See
INDIndia West Bhil0.040050See
DEUGermany DKMS - Bosnia and Herzegovina minority0.03891028See
NZLNew Zealand Maori with Admixed History7.60.0380105See
USAUSA North American Native0.0370187See
USAUSA NMDP Caribean Indian0.036014339See
USAUSA African American pop 40.03532411See
AUSAustralia Cape York Peninsula Aborigine0.0340103See
USAUSA NMDP African American pop 20.0336416581See
BRABrazil Puyanawa6.70.0330150See
DEUGermany DKMS - Greece minority0.03301894See
ISRIsrael Ashkenazi and Non Ashkenazi Jews0.0320146See
USAUSA African American Bethesda6.40.0320187See
CHNChina Han HIV negative0.031072See
CHNChina Henan HIV negative0.031016See
RUSRussia Tuva pop 20.0290169See
GRCGreece pop 60.0289242See
AREUnited Arab Emirates Abu Dhabi0.028852See
RUSRussia Bering Island Aleuts0.0288104See
USAUSA NMDP Caribean Black0.028533328See
GEOGeorgia Tibilisi0.0280109See
ITAItaly South0.0280141See
DEUGermany DKMS - Turkey minority0.02754856See
CHNChina Uyghur HIV negative0.026019See
ESPSpain Andalusia Romani0.026099See
USAUSA South Texas Hispanic0.0260194See
ITAItaly North Pavia0.025081See
USAUSA NMDP African0.024628557See
MEXMexico Mexico City Mestizo population0.0245143See
GRCGreece pop 84.80.024183See
NZLNew Zealand Polynesians with Full Ancestry4.80.024021See
RUSRussia North Ossetian4.70.0236127See
USAUSA South Dakota Lakota Sioux0.0230302See
CHNChina Shanxi HIV negative0.023022See
ENGEngland London Ashkenazi Jews0.0230500See
CMRCameroon Beti0.0230174See
MEXMexico Mexico City Mestizo pop 20.0214234See
LBNLebanon Mixed0.021097See
BFABurkina Faso Rimaibe0.021047See
RUSRussia Transbaikal Territory Buryats4.00.0200150See
USAUSA African American0.0200252See
COLColombia North Wiwa El Encanto0.019252See
NZLNew Zealand Polynesians with Admixed History3.70.019027See
USAUSA NMDP Hawaiian or other Pacific Islander0.018411499See
KENKenya Nandi0.0170240See
GEOGeorgia Tibilisi Kurd0.017031See
USAUSA NMDP Korean0.016277584See
INDIndia Tamil Nadu Nadar0.016061See
GHAGhana Ga-Adangbe3.10.0153131See
ISRIsrael Arab Druze0.0150101See
CHNChina Beijing0.015067See
SDNSudan Mixed3.00.0150200See
AUSAustralia Groote Eylandt Aborigine0.014075See
ZAFSouth Africa Worcester3.00.0130159See
INDIndia Delhi pop 22.50.012090See
KENKenya Luo0.0110265See
NZLNew Zealand Maori with Full Ancestry2.20.011046See
KORSouth Korea pop 10.0110324See
CHNChina North Han pop 20.0106567See
INDIndia North UCBB2.00.01025849See
KORSouth Korea pop 30.0100485See
BFABurkina Faso Fulani0.010049See
CHNChina North Han0.0100105See
CHNChina Inner Mongolia Region0.0100102See
INDIndia Central UCBB2.00.01004204See
TZATanzania Maasai1.90.0094336See
BFABurkina Faso Mossi0.009053See
INDIndia West UCBB1.70.00875829See
USAUSA NMDP Southeast Asian0.008627978See
USAUSA Asian pop 20.00851772See
USAUSA NMDP South Asian Indian0.0084185391See
USAUSA Asian0.0080358See
MLIMali Bandiagara0.0080138See
INDIndia East UCBB1.50.00772403See
DEUGermany DKMS - China minority0.00741282See
USAUSA NMDP Japanese0.007224582See
SAUSaudi Arabia Guraiat and Hail1.40.0070213See
ZWEZimbabwe Harare Shona0.0070230See
AREUnited Arab Emirates Pop 10.0070570See
INDIndia South UCBB1.30.006511446See
UGAUganda Kampala pop 20.0060175See
USAUSA NMDP Filipino0.005450614See
CHNChina Hubei Han1.00.00513732See
CHNChina Guizhou Province Bouyei0.0050109See
CHNChina Qinghai Province Hui0.0050110See
CHNChina Marrow Donor Registry0.0050600See
KENKenya, Nyanza Province, Luo tribe1.00.0050100See
LKASri Lanka Colombo1.00.0050714See
IRNIran Baloch0.0050100See
SGPSingapore Riau Malay0.0050132See
SCOScotland Orkney1.00.005099See
USAUSA Alaska Yupik0.0040252See
JPNJapan pop 10.0040560See
JPNJapan Central0.0040371See
CHNChina Southwest Dai0.0040124See
INDIndia Tamil Nadu0.00382492See
JPNJapan pop 160.003818604See
USAUSA NMDP Chinese0.003699672See
JPNJapan pop 30.00301018See
AUSAustralia Yuendumu Aborigine0.0030191See
MEXMexico Chiapas Lacandon Mayans0.0023218See
MYSMalaysia Peninsular Indian0.40.0018271See
CHNChina South Han pop 20.00181098See
HKGHong Kong Chinese BMDR0.00187595See
INDIndia Northeast UCBB0.30.0017296See
USAUSA NMDP Vietnamese0.001543540See
MYSMalaysia Peninsular Malay0.20.0011951See
TWNTaiwan pop 20.0010364See
TWNTaiwan Han Chinese0.0010504See
RUSRussia Nizhny Novgorod, Russians0.10.00031510See
PHLPhilippines Ivatan0.00.000050See
TWNTaiwan Tsou0.00.000051See
TWNTaiwan Rukai0.00.000050See
TWNTaiwan Paiwan0.00.000051See
TWNTaiwan Ami0.00.000098See
TWNTaiwan Puyuma0.00.000050See
TWNTaiwan Tao0.00.000050See
TWNTaiwan Minnan pop 10.00.0000102See
TWNTaiwan Hakka0.00.000055See
TWNTaiwan Atayal0.00.0000106See
TWNTaiwan Taroko0.00.000055See
TWNTaiwan Saisiat0.00.000051See
TWNTaiwan Bunun0.00.0000101See
TWNTaiwan Pazeh0.00.000055See
TWNTaiwan Siraya0.00.000051See
TWNTaiwan Thao0.00.000030See
ZMBZambia Lusaka0.000044See
INDIndia Mumbai Maratha0.000091See
INDIndia West Coast Parsi0.000050See
CMRCameroon Bamileke0.000077See
CHNChina Guizhou Province Shui0.0000153See
CHNChina Guizhou Province Miao pop 20.000085See
CMRCameroon Sawa0.000013See
CMRCameroon Baka Pygmy0.000010See
BRABrazil Vale do Ribeira Quilombos0.00.0000144See
CHNChina Tibet Region Tibetan0.0000158See
CHNChina Guangzhou0.0000102See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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