News @ AFND

Sponsorship Acknowledgement for the Advancement of AFND

We gratefully acknowledge the generous sponsorship of TxMiller Foundation, whose support has made it possible to initiate the development of the second version of the Allele Frequency Net Database (AFND). Originally launched in 2003, AFND has served the global immunogenetics community for more than two decades as a widely used repository of HLA, KIR, and other immune‐related gene frequency datasets. Thanks to this new funding, we are now beginning a major update, twenty years after the original release, that will modernize the platform, expand its dataset coverage, and advance the next stage of AFND's evolution in support of research, clinical use, among many other contributions.

Introduction

The Allele Frequency Net Database (AFND) provides the scientific community with a freely available repository for the storage of immune gene frequencies in different worldwide populations. Users can contribute the results of their work into one common database and can perform database searches on information already available. We have currently collected data in allele, haplotype and genotype format. However, the success of this website will depend on you to contribute your data.

Does any of this interest you?

• Would you like to publish your population frequency data on HLA and KIR? (In collaboration with Human immunology) See more information in Hum Immunol, 76, 393-394
• New search available for low resolution data when you cannot find the high resolution allele data you want

How good are the data sets in AFND?

We have classified HLA data sets into "Gold-Silver-Bronze" standards. If you wish to see how many populations are classified as Gold, click here.

Please cite this website using our last publication: Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools. Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48, D783-8. [Full Text]
We recommend you to also cite the original publication report of the data in your references.

Polymorphic Region	Population Studies	Gene/Allele Data	Haplotype Data	Genotype Data
HLA	1324	1306	662	-
KIR	293	292	-	192
Cytokine	125	125	-	-
MIC	64	64	23	-
Totals	1,806	1,787	685	192

The current number of frequencies stored in our database is: 156,049 (HLA), 6,731 (KIR), 4,376 (Cytokine) and 877 (MIC) from 14,264,556 individuals.

We have updated the website with the new IMGT/HLA nomenclature guidelines.
IMGT/HLA last Update: 3.37.0, 10 July, 2019. | IPD-KIR last Update: 2.6.0, 17 February, 2015.