Allele Frequencies in World Populations

Does any of this interest you?

- Publish your population frequency data on HLA, KIR, Cytokine, MICA. (In collaboration with Human Immunology)

As you know (AFND) has collected frequency data for many years from normal populations. We have now embarked with the journal HUMAN IMMUNOLOGY (HI) to collect individual genotype data from normal populations. The collection of this data will be the first step leading to a SHORT POPULATION REPORT in HI. The protocol and software tool has been developed on AFND for submission of this data. Once the dataset is submitted to AFND the investigator may then write a short publication for HI. The first announcement of this was made in HI 2015:76 393-94 and more details are available in a recent review of AFND (HI 2016:77 238-248) and in a second editorial in HI 2016:77 617.

01/06/2016 By Derek Middleton

- Contribute to the rare allele project for 17th IHIWS.

Dear Colleagues, we would like to thank your contribution to the "Rare HLA Alleles project", which was considered as part of the past 15th and 16th International HLA and Immunogenetics Workshops (IHIWS) in Buzios and Liverpool respectively. Since last workshop we have been receiving confirmations of rare alleles which data is deposited into the Allele Frequency Net Database (AFND, Some of the contributors have sent data in spreadsheets and others have submitted data directly using the AFND website. As a continuation of this project, we invite people to participate in the project entitled "Study of rare alleles and novel HLA alleles by NGS HLA" which is part of the 17th IHIWS, to be held in Pacific Grove, CA, USA from 6-10 September 2017 ( You can either submit data on an allele that has been sequenced in your laboratory or you may submit material and the allele will be typed by NGS. We also can provide a tool for filtering your rare alleles from a file of individual types. We need your help to ensure this project is successful.

01/06/2016 By Derek Middleton

- New search available for low resolution data

We have included a new search in AFND to allow individuals to look for data at lower resolution. This allows an individual (when data is not available at high resolution for a specific allele) to search frequencies at a lower resolution for this allele family. You can find this link under our main menu (HLA -> Search frequencies at lower resolution).

01/06/2016 By Derek Middleton

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

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