Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 433 time(s) and present in 425 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
NORNorway Sami0.2890200See
ESPSpain Andalusia0.228099See
ARMArmenia Ghegharkunik0.1820242See
RUSRussia Murmansk Saomi Mixed0.180070See
RUSRussia Northwest pop 232.70.1800346See
SWESweden Stockholm32.10.17501347See
GBRUnited Kingdom East0.1748163See
GEOGeorgia Kurds0.172030See
RUSRussia Nenet Mixed0.172055See
IRQIraq Arabs29.50.1678149See
SWESweden pop 430.20.1677966See
ESPSpain Majorcans Jews0.1650103See
ARMArmenia Lori0.1620102See
RUSRussia Northwest29.60.16091011See
RUSRussia Arkhangelsk Pomor0.160063See
RUSRussia South Ural Russian29.00.1590207See
RUSRussia South Ural Tatar28.90.1590135See
HRVCroatia pop 331.70.1583120See
ARMArmenia Yerevan0.1580445See
RUSRussia Chuvash0.158082See
GBRUnited Kingdom Central0.1573135See
BIHBosnia and Herzegovina0.1567134See
NORNorway ethnic Norwegians28.60.15654510See
GBRUnited Kingdom South West0.1564163See
NORNorway pop 20.1550576See
DEUGermany Essen28.70.1540174See
AUTAustria Cord Bloods0.15261368See
RUSRussia Tatars0.1521355See
FRAFrance Reims0.1520102See
RUSRussia Samara Region0.15202500See
ENGEngland Manchester28.00.15141640See
GBRUnited Kingdom North0.1513330See
KURIraq Kurdistan Region27.30.1510209See
RUSRussia Northwest pop 324.00.1500100See
SVNSlovenia pop 327.70.1500130See
ENGEngland Sheffield27.70.14974755See
ENGEngland Liverpool27.20.14671343See
FRAFrance Rennes pop 429.20.14651000See
INDIndia Kerala Hindu Nair0.146041See
ARMArmenia living in Karabakh0.1440445See
CHESwitzerland Bern0.14383545See
ENGEngland Newcastle26.30.14152739See
ESPSpain Pas Valley0.141088See
IRNIran pop 10.141064See
ENGEngland Leeds26.20.14095024See
GBRUnited Kingdom pop 20.1400101See
ARMArmenia living in Lebanon0.1400368See
MEXMexico Baja California, Tijuana0.140025See
USAUSA OPTN Caucasian0.13908525See
WALWales pop 225.90.139039979See
IRQIraq Erbil27.70.1386372See
RUSRussia Moscow Pop 225.50.13842000See
ARMArmenia living in USA0.1370233See
ARMArmenia Syunik0.1370117See
IRLIreland South pop 20.134617624See
RUSRussia Moscow0.13402650See
POLPoland pop 326.60.13332907See
FRAFrance Southeast24.60.1320130See
FRAFrance Grenoble, Nantes and Rennes0.13206094See
ENGEngland Lancaster24.60.1316545See
PAKPakistan Burusho0.130092See
ITAItaly North Pavia0.130081See
FRAFrance Marseille25.90.12981000See
CHESwitzerland Luzern0.12951553See
CHESwitzerland Zurich0.12914875See
ARMArmenia living in Iran0.129085See
SVKSlovakia pop 20.12844234See
ISRIsrael Moroccan Jews0.1280113See
ESPSpain North Cabuerniga0.128095See
FRAFrance Bordeaux25.40.1268990See
ESPSpain Catalonia Girona0.126088See
RUSRussia North Ossetian22.80.1260127See
FRAFrance Grenoble25.10.12551000See
CHESwitzerland Lausanne0.1229993See
CHESwitzerland Graubunden0.1224759See
FRAFrance Lyon24.40.12244813See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks22.30.1210112See
ITAItaly South Campania Region22.70.12081089See
CHESwitzerland Lugano0.11911169See
PRTPortugal Guarda0.1190797See
MKDMacedonia pop 30.1190172See
ARMArmenia Shirak0.118076See
GHAGhana Accre Asutuare Akan0.1180429See
ITAItaly Lombardy21.80.1180674See
IRNIran pop 40.1175855See
PRTAzores Terceira Island0.1170130See
AUSAustralia West Caucasian22.10.1170891See
PRTPortugal Portalegre0.11601254See
ITAItaly North Pavia pop 30.1153685See
PRTPortugal Aveiro0.11505933See
ITAItaly pop 622.30.1141184See
CMRCameroon Uldeme0.114035See
CHESwitzerland Sion0.1139832See
CHESwitzerland Basel0.11331888See
MKDMacedonia MBMDR - Albanian21.90.1133128See
SRBSerbia pop 321.10.11321992See
INDIndia Kerala Syrian Christian0.113031See
BRABrazil REDOME Santa Catarina0.1126106673See
MKDMacedonia pop 40.1120216See
ITAItaly North Pavia pop 220.90.11102416See
BRABrazil Curitiba-Parana Mixed0.1107264See
PRTPortugal Porto0.11007937See
FRAFrance Rennes pop 30.1100200See
ESPSpain Majorca0.1100407See
BRABrazil REDOME Rio Grande do Sul0.1098241329See
PRTPortugal Evora0.1090737See
TURTurkey pop 20.1090228See
PRTPortugal Vila Real0.10801167See
IRNIran Royan Cord Blood Bank20.50.108015600See
PRTPortugal North pop 20.10771801See
BRABrazil Rio Grande do Sul Caucasoid0.10704428See
PRTPortugal Santarem0.10703865See
ESPSpain Arratia Valley Basque0.107083See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.106094See
PRTPortugal Viseu0.10602915See
GAZGaza Palestinians0.1060165See
ITAItaly Rome20.00.1050100See
CHESwitzerland Geneva pop 20.10481267See
VENVenezuela Colonia Tovar0.104786See
MEXMexico Chihuahua Rural0.1046236See
BIHBosnia and Herzegovina pop 220.80.1042120See
ISRIsrael Jews pop 219.60.104023000See
PRTPortugal South pop 20.10401021See
SWESweden Uppsala19.70.1039300See
ESPSpain Sevilla20.10.1025278See
MKDMacedonia MBMDR - Macedonian19.50.10251283See
BRABrazil REDOME Parana0.1015341639See
ESPSpain, Castilla y Leon, Northwest,17.50.10151743See
BRABrazil Paraná Caucasian18.70.1014641See
MEXMexico Zacatecas, Zacatecas city0.101284See
SRBSerbia Vojvodina19.20.1010400See
PRTPortugal Setubal0.10105268See
PRTPortugal Braga0.10101971See
PRTPortugal Coimbra0.10105057See
MEXMexico Chihuahua Chihuahua City0.1008119See
CHESwitzerland Aargau-Solothurn0.10041838See
ENGEngland North West Mixed pop 220.10.1003379See
MARMorocco pop 20.1000110See
TTOTrinidad South Asian0.100087See
ENGEngland London Ashkenazi Jews0.1000500See
MARMorocco Casablanca0.1000100See
ROMRomania pop 319.30.09911469See
PRTPortugal Lisbon0.099017420See
BRABrazil Minas Gerais State Mixed18.50.09801000See
HRVCroatia pop 20.0980100See
ESPSpain Gipuzkoa Basque0.0980100See
ESPSpain Minorca0.098094See
ARGArgentina La Plata19.00.0980100See
SDNSudan East Rashaida18.50.097227See
ALBAlbania pop 218.50.0972432See
PRTPortugal Leiria0.09701847See
PRTPortugal Castelo Branco0.0960327See
ITAItaly Bergamo18.80.0960101See
BRABrazil Parana Cafuzo19.10.0960319See
ALBAlbanian Kosovo0.0958120See
BRABrazil Parana Caucasian18.90.09502775See
SCOScotland Orkney17.00.095099See
BRABrazil REDOME Espirito Santo0.094888485See
PRTPortugal Faro0.09401242See
BRABrazil Sao Paulo Bauru Mixed0.09403542See
BRABrazil REDOME Sao Paulo0.0938800809See
PRTPortugal Viana do Castelo0.0930706See
PRTPortugal Center pop 20.0930562See
PRTMadeira pop 30.0920538See
BRABrazil Rio Grande do Sul Mixed0.0920324See
SDNSudan Khartoum0.091898See
GBRUnited Kingdom Orkney0.091488See
BRABrazil South East Cord Blood0.091311409See
GRCGreece pop 70.091311250See
BRABrazil REDOME Sergipe0.09117321See
AREUnited Arab Emirates pop 217.40.0910373See
BRABrazil Parana Mixed race18.30.0910186See
ROMRomania pop 20.09006936See
TTOTrinidad African0.090067See
BRABrazil REDOME Rio de Janeiro0.0898139322See
CHESwitzerland St Gallen0.08932113See
BRABrazil REDOME Alagoas0.089125349See
BRABrazil REDOME Rondonia0.089054396See
BRABrazil REDOME Bahia0.088847399See
BRABrazil REDOME Mato Grosso0.088334649See
BRABrazil REDOME Minas Gerais0.0882211275See
ARGArgentina Buenos Aires17.00.0880466See
INDIndia Kerala Malabar Muslim0.088034See
SAUSaudi Arabia16.70.087318See
GRCGreece pop316.70.0873246See
ESPSpain Murcia0.0870173See
ARGArgentina Buenos Aires pop 217.00.08701216See
BRABrazil REDOME Federal District0.087029549See
BRABrazil REDOME Mato Grosso do Sul0.086895667See
SDNSudan Central Shaigiya Mixed16.60.086736See
BRABrazil REDOME Goias0.086388574See
BRABrazil REDOME Acre0.0862859See
RUSRussia South Ural Bashkir16.40.0860146See
ESPSpain Ibiza0.086088See
ZAFSouth Africa Tswana17.10.085041See
BRABrazil REDOME Tocantins0.084520692See
BRABrazil Pernambuco Mixed0.0840101See
DZAAlgeria pop 216.00.0834106See
MEXMexico Jalisco, Tlajomulco0.083330See
CUBCuba Mixed Race16.70.083042See
INDIndia Kerala Hindu Ezhava0.083024See
ESPSpain Majorca and Minorca0.083090See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.083096See
BRABrazil REDOME Pernambuco0.083092332See
TUNTunisia pop 30.0820104See
MEXMexico Queretaro Rural0.081443See
BRABrazil REDOME Ceara0.0813101217See
CZECzech Republic Kurd14.90.081174See
PRTPortugal Beja0.0810699See
PRTPortugal Bragança0.0810301See
INDIndia Bikaner Non-Raikas15.50.0810127See
BRABrazil REDOME Piaui0.080546140See
USAUSA OPTN African American0.08001510See
CUBCuba Mixed pop 20.0800189See
GRCGreece North0.0800500See
MEXMexico Baja California Rural0.080050See
MEXMexico Colima Rural0.079543See
MNGMongolia Tarialan Khoton0.079085See
MNGMongolia Hoton0.079085See
BRABrazil Piaui Mixed0.079021943See
BRABrazil REDOME Paraiba0.078343868See
ESPSpain North Cantabria0.078083See
TURTurkey pop 50.0780142See
INDIndia Jalpaiguri Toto15.00.078040See
BRABrazil Parana Afro Brazilian15.60.078077See
BRABrazil REDOME Rio Grande do Norte0.077846603See
INDIndia North pop 30.0770587See
BRABrazil Rio Grande do Norte Mestizo0.077012973See
BRABrazil REDOME Maranhao0.076010180See
MEXMexico Chiapas, Tuxtla Gutierrez0.075552See
MEXMexico Nuevo Leon, Monterrey city0.0752226See
VENVenezuela Zulia Maracaibo Mixed0.075020See
VENVenezuela Zulia San Jose de Heras Mixed0.075020See
GRCGreece Crete0.0750135See
USAUSA OPTN Hispanic0.07401580See
BRABrazil South Ribeirao Preto0.0740184See
INDIndia North Gujarat13.90.0740338See
ARGArgentina Cuyo Region14.00.0730420See
SAUSaudi Arabia pop 413.00.0721499See
COLColombia San Basilio de Palenque0.071042See
CHLChile Santiago0.0701920See
BRABrazil REDOME Para0.069072637See
MNGMongolia Tsaatan0.0690144See
MEXMexico Nuevo Leon Rural0.0682439See
BRABrazil Para State14.40.06825000See
FRAFrance Corsica Island0.0670100See
MEXMexico San Luis Potosi, San Luis Potosi city0.066730See
BRABrazil Para Cord Blood Unit13.10.0666841See
BRABrazil REDOME Roraima0.06644140See
MEXMexico Coahuila, Torreon0.0663396See
MEXMexico Sonora Rural0.0660197See
PRTMadeira pop 20.0660173See
ARGArgentina Corrientes12.30.0640155See
BRABrazil Rio Grande do Sul Black0.0640248See
BRABrazil REDOME Amapa0.063317864See
MEXMexico Sinaloa, Culiacán0.0631103See
SAUSaudi Arabia pop 20.0630383See
INDIndia Kerala Hindu Pulaya0.063016See
MEXMexico Sonora, Ciudad Obregón0.0629143See
BRABrazil REDOME Amazonas0.062224129See
MEXMexico Jalisco Rural0.0614585See
COLColombia Barranquilla0.0610188See
MEXMexico Sonora, Hermosillo0.060699See
ITAItaly East Sicily12.00.060050See
MNGMongolia Khalkha0.0600200See
ZAFSouth Africa Natal Zulu12.00.0600100See
MNGMongolia Oold0.0580104See
MEXMexico Jalisco, Tonala0.057135See
MEXMexico Zacatecas, Fresnillo0.0571103See
BRABrazil Sao Paulo Mixed11.00.0570239See
PAKPakistan Mixed Sindhi0.0570101See
ISRIsrael Ashkenazi Jews pop 20.0570132See
CMRCameroon Bamileke 20.057035See
MEXMexico Michoacan, Morelia0.0563150See
CUBCuba Mixed0.056078See
MEXMexico Zacatecas Rural0.0558266See
MEXMexico Coahuila Rural0.0550216See
MEXMexico Baja Californa, Mexicali0.0550100See
MEXMexico Coahuila, Saltillo0.054872See
MEXMexico Durango, Durango city0.0548153See
MEXMexico Sinaloa Rural0.0546183See
CZECzech Republic Romani pop 28.70.054446See
MEXMexico Sinaloa Mestizo0.054056See
MEXMexico Jalisco, Guadalajara city0.05401189See
MEXMexico Campeche Rural0.053247See
MEXMexico Mestizo pop 40.0520269See
MEXMexico Jalisco, Tlaquepaque0.051339See
MEXMexico Veracruz, Orizaba0.050060See
MEXMexico Morelos Rural0.050030See
ECUEcuador Andes Mixed Ancestry0.0479824See
CHNChina Shaanxi Province Han0.047010000See
MEXMexico Nayarit, Tepic0.046497See
ECUEcuador Mixed Ancestry0.04561173See
BRABrazil Parana Oriental9.10.045033See
MEXMexico Guanajuato, Leon0.044978See
SDNSudan South Nuba8.70.044446See
MEXMexico Campeche, Campeche city0.044134See
CHNChina Harbin Manchu0.0440172See
MEXMexico Hidalgo Rural0.043281See
TWNTaiwan Chinese immigrants from North China0.0430152See
CHNChina Shandong Province8.30.04307418See
MEXMexico Tabasco Rural0.0423142See
MEXMexico Mexico City Center0.0422152See
MEXMexico Mexico City Mestizo0.0410121See
CMRCameroon Bakola Pygmy8.00.040850See
MEXMexico Veracruz, Xalapa0.0401187See
MEXMexico Quintana Roo Rural0.040050See
RUSRussia Transbaikal Territory Buryats8.00.0400150See
MEXMexico Baja California, La Paz0.040075See
CMRCameroon Ewondo0.040038See
ECUEcuador Coast Mixed Ancestry0.0399238See
MEXMexico Guanajuato Rural0.0399162See
MEXMexico Mexico City Metropolitan Area Rural0.0395150See
MEXMexico Jalisco, Zapopan0.0387168See
INDIndia Kerala Hindu Namboothiri0.038040See
MNGMongolia Ulaanbaatar Khalkha0.038041See
MEXMexico Yucatan Rural0.0373132See
MEXMexico Chiapas Rural0.0372121See
MEXMexico Michoacan Rural0.0372348See
BRABrazil Parana Japanese7.00.0370192See
CHNChina Wuhan7.40.0370121See
MEXMexico Aguascalientes state0.036895See
ITAItaly Sardinia pop30.0360100See
GTMGuatemala, Guatemala City Mixed Ancestry6.30.0354127See
MEXMexico Durango Rural0.0352326See
MEXMexico Mexico City Mestizo pop 30.0350256See
LKASri Lanka Colombo Sinhalese0.0350101See
CMRCameroon Podokwo0.035043See
BGDBangladesh Dhaka Bangalee0.0350141See
MEXMexico Guerrero state0.0347144See
CHNChina Shandong Province Linqu County6.50.0330139See
MEXMexico Mexico City North0.0325751See
MEXMexico Veracruz Rural0.0323539See
MEXMexico Mexico City East0.031379See
MEXMexico Quintana Roo, Cancun0.031348See
MEXMexico Puebla, Puebla city0.03031994See
MNGMongolia Khalkha pop 20.0300202See
MYSMalaysia Negeri Sembilan Minangkabau0.030034See
MEXMexico Veracruz, Veracruz city0.0291171See
MEXMexico Yucatan, Merida0.0282192See
CHNChina Yunnan Province Naxi0.0280118See
RUSRussia Sakhalin Island Nivkhi0.028053See
BFABurkina Faso Mossi0.028053See
MEXMexico Tamaulipas Rural0.0278125See
MEXMexico Oaxaca, Oaxaca city0.0265151See
MEXMexico Puebla Rural0.0264833See
MKDMacedonia MBMDR - Macedonian Muslims5.30.026376See
INDIndia Bikaner Raikas5.00.0260143See
USAUSA OPTN Asian0.0260261See
ECUEcuador Amazonia Mixed Ancestry0.025639See
CHNChina Yunnan Province Han pop 20.0250129See
MEXMexico Colima, Colima city0.024661See
MEXMexico Tabasco, Villahermosa0.024482See
CHNChina Jiangsu Province0.024020248See
MYSMalaysia pop 20.024062See
MEXMexico Mestizo4.90.024041See
MMRMyanmar Mon4.70.023464See
MEXMexico Nayarit Rural0.023464See
MEXMexico Chihuahua, Ciudad Juarez0.0231106See
MEXMexico San Luis Potosi Rural0.023087See
MMRMyanmar Kayin4.50.022744See
MEXMexico Oaxaca Rural0.0226485See
MEXMexico Tlaxcala Rural0.0223830See
CHNChina Harbin Korean0.0220201See
BOLBolivia Quechua0.021769See
CHNChina Guangdong Province4.20.0212403See
BFABurkina Faso Rimaibe0.021047See
MEXMexico Tapachula, Chiapas Mestizo Population4.20.020872See
PHLPhilippines National Capital Region0.020051See
BFABurkina Faso Fulani0.020049See
KORSouth Korea pop 10.0200324See
MYSMalaysia Perak Rawa0.020023See
KORSouth Korea pop 80.02007096See
MEXMexico Tlaxcala, Tlaxcala city0.0193181See
GTMGuatemala Mayan0.0190132See
MYSMalaysia pop 30.01901445See
CHNChina Shanghai0.019026266See
MEXMexico Morelos, Cuernavaca0.018382See
TUNTunisia Ghannouch0.018082See
MEXMexico Veracruz, Cordoba0.017956See
TWNTaiwan Chinese immigrants from Middle China0.0170211See
ARGArgentina Rosario Toba3.50.017086See
MEXMexico Sinaloa Capomos Mayo Yoremes0.016760See
JPNJapan Hyogo3.10.016032See
CAFCentral African Republic Mbenzele Pygmy3.00.015136See
MEXMexico Hidalgo, Pachuca0.012241See
PERPeru Lamas City Lama0.012083See
MEXMexico Veracruz, Poza Rica0.011145See
MEXMexico Queretaro, Queretaro city0.011145See
MMRMyanmar Bamar2.20.010946See
MMRMyanmar Rakhine2.10.010448See
JPNJapan Hyogo Osaka and Nagano0.0100195See
VENVenezuela Caracas Mestizo0.010050See
MYSMalaysia Sarawak Iban0.010051See
MYSMalaysia Sarawak Bidayuh0.010050See
MEXMexico Puebla Mestizo0.010099See
VNMVietnam Hanoi0.010050See
MEXMexico Mexico City South0.009652See
INDIndia sub-Himalayan West Bengal Kami1.90.0095158See
THAThailand pop 40.009016807See
MEXMexico Veracruz, Coatzacoalcos0.008955See
MMRMyanmar Kachin1.60.007963See
BOLBolivia La Paz Aymaras0.006087See
JPNJapan pop 20.0060916See
THAThailand Northeast0.004066See
THAThailand Northeast pop 20.0040400See
TWNTaiwan Hakka pop 20.0030714See
TWNTaiwan Minnan pop 20.00307137See
TWNTaiwan Chinese immigrants from South China0.0030172See
TWNTaiwan Aborigine0.0000111See
MEXMexico Huasteca Region Teenek0.000055See
ARGArgentina Chiriguano0.00.000054See
ARGArgentina Salta Wichi pop 20.00.000019See
CHNChina North Han0.0000105See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Guanajuato, Guanajuato city0.000022See
MEXMexico Mexico City West0.000033See

See also higher resolution data of this allele

Allele  Number of Populations 
 A*03:01 275 
 A*03:01:01 60 
 A*03:01:01:01 22 
 A*03:01:02 29 
 A*03:01:03 10 
 A*03:02 197 
 A*03:02:01 17 
 A*03:03N 16 
 A*03:04 39 
 A*03:05 51 
 A*03:06 18 
 A*03:07 28 
 A*03:08 27 
 A*03:09 18 
 A*03:10 13 
 A*03:12 12 
 A*03:13 10 
 A*03:14 10 
 A*03:16 10 
 A*03:42 11 
 A*03:50 13 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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