Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele at this level. If an allele has an entry with a higher resolution this will be shown at the end.



Allele reported 333 time(s) and present in 247 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
CMRCameroon Ewondo0.145038See
CMRCameroon Uldeme0.057035See
CMRCameroon Bamileke 20.043035See
ZAFSouth Africa Tswana7.30.037041See
PERPeru Lamas City Lama0.036083See
CMRCameroon Podokwo0.035043See
ZAFSouth Africa Natal Zulu7.00.0350100See
SDNSudan South Nuba6.50.033046See
GHAGhana Accre Asutuare Akan0.0320429See
CHNChina Yunnan Province Han pop 20.0290129See
CUBCuba Mixed pop 20.0270189See
CZECzech Republic Kurd5.40.027074See
CUBCuba Mixed Race4.80.023042See
MARMorocco pop 20.0230110See
MEXMexico San Luis Potosi Rural0.023087See
USAUSA OPTN African American0.02301510See
MEXMexico Puebla Mestizo0.020099See
COLColombia Barranquilla0.0185188See
PRTPortugal North pop 20.01701801See
MEXMexico Jalisco, Tlajomulco0.016730See
MEXMexico San Luis Potosi, San Luis Potosi city0.016730See
MEXMexico Chiapas Rural0.0165121See
MYSMalaysia Perak and Johor Banjar Bugis Jawa0.016094See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.016096See
MEXMexico Baja Californa, Mexicali0.0150100See
ARMArmenia Lori0.0150102See
BRABrazil REDOME Pernambuco0.014692332See
MEXMexico Zacatecas, Fresnillo0.0143103See
BRABrazil REDOME Bahia0.014247399See
BRABrazil REDOME Sergipe0.01417321See
BRABrazil Minas Gerais State Mixed2.60.01401000See
PRTPortugal Viseu0.01402915See
MEXMexico Durango Rural0.0138326See
BRABrazil Piaui Mixed0.013021943See
BRABrazil REDOME Maranhao0.013010180See
ARMArmenia Shirak0.013076See
BRABrazil Parana Mixed race2.70.0130186See
BRABrazil Parana Afro Brazilian2.60.013077See
ISRIsrael Jews pop 22.70.013023000See
BRABrazil REDOME Rio de Janeiro0.0129139322See
BRABrazil REDOME Paraiba0.012843868See
BRABrazil REDOME Tocantins0.012620692See
BRABrazil South East Cord Blood0.012511409See
BRABrazil REDOME Piaui0.012446140See
BRABrazil Rio Grande do Sul Black0.0120248See
AREUnited Arab Emirates pop 22.40.0120373See
COLColombia San Basilio de Palenque0.012042See
PRTAzores Terceira Island0.0120130See
BRABrazil REDOME Minas Gerais0.0119211275See
BRABrazil REDOME Roraima0.01114140See
BRABrazil REDOME Alagoas0.011125349See
SVKSlovakia pop 20.01114234See
BRABrazil South Ribeirao Preto0.0110184See
BRABrazil Rio Grande do Norte Mestizo0.011012973See
BRABrazil REDOME Federal District0.011029549See
BRABrazil Parana Cafuzo2.10.0110319See
PRTPortugal Braga0.01101971See
PRTPortugal Viana do Castelo0.0110706See
PRTPortugal Vila Real0.01101167See
PRTPortugal Evora0.0110737See
CZECzech Republic Romani pop 22.20.010946See
BRABrazil REDOME Espirito Santo0.010788485See
BRABrazil REDOME Goias0.010788574See
MEXMexico Tabasco Rural0.0106142See
MEXMexico Chihuahua Rural0.0105236See
BRABrazil REDOME Rio Grande do Norte0.010446603See
BRABrazil Curitiba-Parana Mixed0.0103264See
MEXMexico Nayarit, Tepic0.010397See
MEXMexico Baja California Rural0.010050See
MEXMexico Michoacan Rural0.0100348See
MARMorocco Casablanca0.0100100See
MYSMalaysia Negeri Sembilan Minangkabau0.010034See
BRABrazil REDOME Ceara0.0100101217See
TTOTrinidad African0.010067See
IRNIran pop 40.0099855See
MEXMexico Mexico City South0.009652See
BRABrazil REDOME Mato Grosso do Sul0.009595667See
MEXMexico San Vicente Tancuayalab Teenek/Huastecos0.009453See
BRABrazil REDOME Mato Grosso0.009434649See
BRABrazil REDOME Rondonia0.009354396See
BRABrazil REDOME Sao Paulo0.0091800809See
BRABrazil REDOME Para0.009072637See
BRABrazil Para State0.90.00905000See
ARMArmenia Syunik0.0090117See
MEXMexico Sinaloa Mestizo0.009056See
MEXMexico Huasteca Region Teenek0.009055See
PRTPortugal Guarda0.0090797See
GAZGaza Palestinians0.0090165See
MEXMexico Jalisco, Zapopan0.0089168See
MEXMexico Veracruz, Cordoba0.008956See
MEXMexico Jalisco Rural0.0085585See
POLPoland pop 31.70.00832907See
BRABrazil REDOME Amapa0.008317864See
HRVCroatia pop 31.70.0083120See
BRABrazil REDOME Acre0.0082859See
MEXMexico Sinaloa Rural0.0082183See
ITAItaly Lombardy1.60.0080674See
PRTPortugal Aveiro0.00805933See
PRTPortugal Lisbon0.008017420See
PRTPortugal Portalegre0.00801254See
PRTPortugal Porto0.00807937See
PRTPortugal Bragança0.0080301See
ARMArmenia living in Lebanon0.0080368See
ARMArmenia Ghegharkunik0.0080242See
BRABrazil Rio Grande do Sul Caucasoid0.00804428See
ARMArmenia Yerevan0.0080445See
CUBCuba Mixed0.008078See
SVNSlovenia pop 31.50.0080130See
GTMGuatemala, Guatemala City Mixed Ancestry1.60.0079127See
RUSRussia North Ossetian1.60.0079127See
BRABrazil REDOME Parana0.0078341639See
RUSRussia Moscow Pop 21.60.00782000See
BRABrazil REDOME Amazonas0.007724129See
ESPSpain, Castilla y Leon, Northwest,1.40.00761743See
BIHBosnia and Herzegovina0.0074134See
ESPSpain Sevilla1.40.0072278See
ESPSpain Arratia Valley Basque0.007083See
GRCGreece North0.0070500See
FRAFrance Rennes pop 41.40.00701000See
CHNChina Shandong Province Linqu County1.40.0070139See
ENGEngland London Ashkenazi Jews0.0070500See
BRABrazil Parana Caucasian1.50.00702775See
BRABrazil Sao Paulo Bauru Mixed0.00703542See
RUSRussia South Ural Russian1.40.0070207See
RUSRussia Samara Region0.00702500See
PRTPortugal Setubal0.00705268See
PRTPortugal Coimbra0.00705057See
PRTMadeira pop 30.0070538See
PRTPortugal Beja0.0070699See
PRTPortugal South pop 20.00701021See
PERPeru Arequipa Mestizo1.40.0070168See
RUSRussia South Ural Tatar1.50.0070135See
MEXMexico Coahuila Rural0.0069216See
IRQIraq Arabs1.30.0067149See
MEXMexico Baja California, La Paz0.006775See
BRABrazil REDOME Rio Grande do Sul0.0067241329See
ITAItaly North Pavia pop 30.0066685See
MEXMexico Mexico City Metropolitan Area Rural0.0066150See
MEXMexico Veracruz Rural0.0065539See
MEXMexico Mexico City Center0.0065152See
BRABrazil REDOME Santa Catarina0.0065106673See
ECUEcuador Coast Mixed Ancestry0.0063238See
ITAItaly North Pavia pop 21.30.00602416See
BRABrazil Rio Grande do Sul Mixed0.0060324See
ARGArgentina Cuyo Region1.20.0060420See
PRTMadeira pop 20.0060173See
PRTPortugal Santarem0.00603865See
PRTPortugal Faro0.00601242See
RUSRussia Moscow0.00602650See
SAUSaudi Arabia pop 41.20.0060499See
RUSRussia Tatars0.0056355See
MEXMexico Mestizo pop 40.0056269See
GRCGreece pop 70.005611250See
BRABrazil Paraná Caucasian1.10.0055641See
ITAItaly pop 61.10.0054184See
MEXMexico Aguascalientes state0.005395See
MEXMexico Veracruz, Xalapa0.0053187See
MEXMexico Sonora, Hermosillo0.005199See
MEXMexico Sonora Rural0.0051197See
FRAFrance Lyon1.00.00514813See
FRAFrance Reims0.0050102See
ITAItaly Rome1.00.0050100See
IRNIran Royan Cord Blood Bank1.00.005015600See
DZAAlgeria pop 21.00.0050106See
ARGArgentina Buenos Aires pop 21.20.00501216See
MNGMongolia Khalkha0.0050200See
PRTPortugal Castelo Branco0.0050327See
RUSRussia Northwest pop 31.00.0050100See
TWNTaiwan Aborigine0.0050111See
KURIraq Kurdistan Region1.00.0050209See
USAUSA OPTN Hispanic0.00501580See
FRAFrance Grenoble0.90.00431000See
BIHBosnia and Herzegovina pop 20.80.0042120See
MEXMexico Chihuahua Chihuahua City0.0042119See
BRABrazil Para Cord Blood Unit0.00.0042841See
ARMArmenia living in USA0.0040233See
ARGArgentina La Plata1.00.0040100See
ARGArgentina Buenos Aires0.90.0040466See
FRAFrance Southeast0.80.0040130See
ENGEngland Manchester0.80.00401640See
PRTPortugal Leiria0.00401847See
USAUSA OPTN Caucasian0.00408525See
ECUEcuador Mixed Ancestry0.00381173See
SRBSerbia pop 30.80.00381992See
MEXMexico Zacatecas Rural0.0037266See
MEXMexico Yucatan Rural0.0037132See
ECUEcuador Andes Mixed Ancestry0.0036824See
SWESweden pop 40.70.0036966See
MKDMacedonia MBMDR - Macedonian0.70.00351283See
MEXMexico Guerrero state0.0035144See
MEXMexico Sonora, Ciudad Obregón0.0035143See
ENGEngland Liverpool0.70.00351343See
ENGEngland Newcastle0.70.00352739See
ROMRomania pop 30.70.00341469See
MEXMexico Michoacan, Morelia0.0033150See
NORNorway ethnic Norwegians0.70.00334510See
FRAFrance Marseille0.60.00321000See
INDIndia sub-Himalayan West Bengal Kami0.60.0032158See
MEXMexico Guanajuato Rural0.0031162See
RUSRussia South Ural Bashkir0.70.0030146See
ITAItaly South Campania Region0.60.00301089See
FRAFrance Grenoble, Nantes and Rennes0.00306094See
ENGEngland Sheffield0.60.00304755See
MEXMexico Jalisco, Guadalajara city0.00291189See
MEXMexico Tlaxcala, Tlaxcala city0.0028181See
CHLChile Santiago0.0027920See
FRAFrance Bordeaux0.50.0027990See
IRQIraq Erbil0.50.0027372See
IRLIreland South pop 20.002717624See
ENGEngland North West Mixed pop 20.50.0026379See
MEXMexico Puebla, Puebla city0.00251994See
MEXMexico Coahuila, Torreon0.0025396See
MEXMexico Oaxaca Rural0.0021485See
MEXMexico Mexico City North0.0020751See
MKDMacedonia pop 40.0020216See
ENGEngland Lancaster0.40.0020545See
ENGEngland Leeds0.40.00205024See
GRCGreece pop30.40.0020246See
AUSAustralia West Caucasian0.50.0020891See
WALWales pop 20.50.002039979See
SRBSerbia Vojvodina0.50.0020400See
MEXMexico Puebla Rural0.0018833See
SWESweden Uppsala0.30.0015300See
ALBAlbania pop 20.20.0012432See
MEXMexico Nuevo Leon Rural0.0011439See
ARMArmenia living in Karabakh0.0010445See
CHNChina Shandong Province0.20.00107418See
CHNChina Shaanxi Province Han0.001010000See
CHNChina Jiangsu Province0.001020248See
SAUSaudi Arabia pop 20.0010383See
INDIndia North pop 30.0009587See
MEXMexico Tlaxcala Rural0.0006830See
CHNChina Shanghai0.000426266See
CHNChina Yunnan Province Naxi0.0000118See
ECUEcuador Amazonia Mixed Ancestry0.000039See
ESPSpain Majorca0.0000407See
ESPSpain Minorca0.000094See
ESPSpain Ibiza0.000088See
ESPSpain Majorcans Jews0.0000103See
ESPSpain Murcia0.0000173See
HRVCroatia pop 20.0000100See
ITAItaly Sardinia pop30.0000100See
GBRUnited Kingdom pop 20.0000101See
FRAFrance Corsica Island0.0000100See
ESPSpain Gipuzkoa Basque0.0000100See
ESPSpain Catalonia Girona0.000088See
ESPSpain Majorca and Minorca0.000090See
CHNChina Harbin Manchu0.0000172See
CHNChina Harbin Korean0.0000201See
CHNChina North Han0.0000105See
ARGArgentina Corrientes0.00.0000155See
ARGArgentina Rosario Toba0.00.000086See
ARGArgentina Chiriguano0.00.000054See
ARGArgentina Salta Wichi pop 20.00.000019See
BRABrazil Sao Paulo Mixed0.00.0000239See
BRABrazil Parana Oriental0.00.000033See
MEXMexico Campeche Rural0.000047See
MEXMexico Quintana Roo Rural0.000050See
MEXMexico Baja California, Tijuana0.000025See
MEXMexico Hidalgo Rural0.000081See
MEXMexico Queretaro Rural0.000043See
MEXMexico Tamaulipas Rural0.0000125See
MEXMexico Morelos Rural0.000030See
MEXMexico Colima Rural0.000043See
MEXMexico Nayarit Rural0.000064See
MEXMexico Mexico City Mestizo0.0000121See
MEXMexico Mestizo0.00.000041See
JPNJapan Hyogo Osaka and Nagano0.0000195See
KORSouth Korea pop 10.0000324See
MEXMexico Sinaloa, Culiacán0.0000103See
MEXMexico Chihuahua, Ciudad Juarez0.0000106See
MEXMexico Coahuila, Saltillo0.000072See
MEXMexico Durango, Durango city0.0000153See
MEXMexico Zacatecas, Zacatecas city0.000084See
MEXMexico Queretaro, Queretaro city0.000045See
MEXMexico Jalisco, Tonala0.000035See
MEXMexico Jalisco, Tlaquepaque0.000039See
MEXMexico Nuevo Leon, Monterrey city0.0000226See
MEXMexico Colima, Colima city0.000061See
MEXMexico Guanajuato, Leon0.000078See
MEXMexico Guanajuato, Guanajuato city0.000022See
MEXMexico Veracruz, Poza Rica0.000045See
MEXMexico Veracruz, Orizaba0.000060See
MEXMexico Veracruz, Coatzacoalcos0.000055See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
RUSRussia Nenet Mixed0.000055See
RUSRussia Arkhangelsk Pomor0.000063See
RUSRussia Murmansk Saomi Mixed0.000070See
RUSRussia Northwest0.00.00001011See
MYSMalaysia pop 20.000062See
MNGMongolia Oold0.0000104See
MNGMongolia Tsaatan0.0000144See
MNGMongolia Hoton0.000085See
MNGMongolia Khalkha pop 20.0000202See
PAKPakistan Burusho0.000092See
PAKPakistan Mixed Sindhi0.0000101See
MYSMalaysia Perak Rawa0.000023See
MEXMexico Mexico City East0.000079See
MEXMexico Hidalgo, Pachuca0.000041See
MEXMexico Veracruz, Veracruz city0.0000171See
MEXMexico Morelos, Cuernavaca0.000082See
MEXMexico Oaxaca, Oaxaca city0.0000151See
MEXMexico Quintana Roo, Cancun0.000048See
MEXMexico Mexico City West0.000033See
MEXMexico Yucatan, Merida0.0000192See
MEXMexico Campeche, Campeche city0.000034See
MEXMexico Chiapas, Tuxtla Gutierrez0.000052See
MEXMexico Tabasco, Villahermosa0.000082See
SCOScotland Orkney0.00.000099See
SWESweden Stockholm0.10.00001347See
THAThailand pop 40.000016807See
TTOTrinidad South Asian0.000087See
TWNTaiwan Hakka pop 20.0000714See
USAUSA South Texas Hispanic0.0000194See
USAUSA OPTN Asian0.0000261See
TURTurkey pop 50.0000142See
TWNTaiwan Minnan pop 20.00007137See
TWNTaiwan Chinese immigrants from South China0.0000172See
TWNTaiwan Chinese immigrants from Middle China0.0000211See
TWNTaiwan Chinese immigrants from North China0.0000152See

See also higher resolution data of this allele

Allele  Number of Populations 
 A*66:01 236 
 A*66:01:01 21 
 A*66:02 123 
 A*66:03 92 
 A*66:04 14 
 A*66:05 17 
 A*66:07 15 

* This list corresponds to those alleles that have been reported in AFND only (i.e. only positive findings).


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

Valid XHTML 1.0 Transitional