Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.

Allele: 
   

DRB1*16

 
Allele reported 364 time(s) and present in 353 population(s).

Population Phenotype
Frequency (%)
Allele
Frequency
(in_decimals)
Sample
Size
IMGT/HLA¹
Database
Distribution² Haplotype³
Association
Notesª
BRABrazil Guarani M bya0.371093See
AREUnited Arab Emirates pop 233.00.1810373See
MKDMacedonia MBMDR - Macedonian Muslims31.60.171176See
PAKPakistan Brahui0.1700104See
COLColombia Northwest Tule0.155029See
MEXMexico Oaxaca, Oaxaca city0.1490151See
MKDMacedonia MBMDR - Macedonian27.50.14691283See
MKDMacedonia0.1469286See
ALBAlbanian Kosovo0.1375120See
GRCGreece pop 70.133711250See
PAKPakistan Baloch0.132066See
GRCGreece pop 50.1310500See
BRABrazil Kaingang0.1250235See
ALBAlbania0.1240160See
ALBAlbania pop 223.60.1215432See
ITAItaly Sardinia0.121086See
CZECzech Republic Gypsy pop 221.70.119646See
HRVCroatia pop 20.1180100See
MKDMacedonia MBMDR - Albanian20.30.1094128See
SRBSerbia pop 320.40.10871992See
ROMRomania pop 320.30.10721469See
SRBSerbia0.1050386See
ROMRomania pop 20.10006936See
BIHBosnia and Herzegovina pop 219.20.1000120See
HRVCroatia pop 320.00.1000120See
GRCGreece North0.1000500See
MEXMexico Veracruz, Coatzacoalcos0.098255See
BIHBosnia and Herzegovina0.0970134See
MEXMexico Puebla Rural0.0965833See
MEXMexico Mexico City South0.096252See
MEXMexico Oaxaca Rural0.0945485See
MEXMexico Guerrero state0.0903144See
MEXMexico Mexico City Metropolitan Area Rural0.0888150See
UKRUkraine Khmelnytskyi0.0870138See
ARGArgentina Corrientes14.80.0870155See
MEXMexico Puebla, Puebla city0.08671994See
SRBSerbia Vojvodina15.50.0820400See
TURTurkey Istanbul15.60.0813250See
MEXMexico Puebla Mestizo0.081099See
MEXMexico Tlaxcala Rural0.0795830See
BLRBelarus Gomel Region0.0790100See
MEXMexico Veracruz Rural0.0702539See
TURTurkey Ankara0.070050See
MEXMexico San Luis Potosi Rural0.069087See
ITAItaly North Pavia pop 30.0683685See
ITAItaly North Pavia0.068081See
ITAItaly North Pavia pop 213.90.06802416See
MEXMexico Mexico City North0.0677751See
BLRBelarus Brest Region0.0670105See
MEXMexico Veracruz, Orizaba0.066760See
MEXMexico Queretaro, Queretaro city0.066745See
MEXMexico Tlaxcala, Tlaxcala city0.0663181See
BRABrazil REDOME Amazonas0.065624129See
MEXMexico Tamaulipas, Ciudad Victoria0.065223See
BRABrazil REDOME Amapa0.064717864See
ECUEcuador Amazonia Mixed Ancestry0.064139See
ITAItaly Lombardy12.30.0640674See
MEXMexico Nuevo Leon Rural0.0625439See
SVKSlovakia pop 20.06204234See
ESPSpain Malaga Gypsy12.00.061980See
MEXMexico Coahuila, Saltillo0.061672See
MEXMexico Veracruz, Veracruz city0.0610171See
BRABrazil REDOME Para0.061072637See
ARGArgentina Kolla0.060061See
MEXMexico Tamaulipas Rural0.0595125See
UKRUkraine Lvov0.0590102See
ARMArmenia Shirak0.059076See
BRABrazil REDOME Roraima0.05854140See
MEXMexico Mexico City Center0.0584152See
POLPoland pop 311.60.05802907See
MEXMexico Colima Rural0.056843See
MEXMexico Nayarit, Tepic0.056797See
MEXMexico Tabasco, Villahermosa0.054982See
TWNTaiwan Chinese immigrants from South China0.0540172See
SVKSlovakia0.0540146See
MEXMexico Mestizo pop 40.0539269See
MEXMexico Veracruz, Xalapa0.0535187See
RUSRussia South Ural Tatar10.40.0520135See
MEXMexico Durango, Durango city0.0516153See
MEXMexico Jalisco, Tlaquepaque0.051339See
CHNChina Beijing and Guangzhou0.05101592See
MEXMexico Jalisco, Zapopan0.0506168See
MEXMexico San Luis Potosi, San Luis Potosi city0.050030See
MEXMexico Mexico City East0.050079See
BRABrazil REDOME Maranhao0.050010180See
MEXMexico mestizo pop 30.0497201See
MEXMexico Chiapas Rural0.0496121See
BRABrazil REDOME Piaui0.048846140See
BRABrazil Piaui Mixed0.048021943See
BRABrazil REDOME Acre0.0477859See
BRABrazil Curitiba-Parana Mixed0.0475264See
MEXMexico Aguascalientes state0.047495See
ITAItaly pop 20.047053See
THAThailand pop 40.047016807See
BRABrazil North East Mixed0.0470205See
CHESwitzerland Luzern0.04691553See
MEXMexico Nayarit Rural0.046964See
ITAItaly pop 69.20.0462184See
MEXMexico Mexico City Mestizo0.0460121See
RUSRussia Moscow0.04602650See
ECUEcuador Mixed Ancestry0.04521173See
COLColombia Antioquia Paisa0.0450100See
ITAItaly South Campania Region8.80.04501089See
ITAItaly pop 48.80.04504575See
BLRBelarus Vitebsk Region0.045070See
RUSRussia Moscow Pop 28.80.04502000See
CHNChina Guangdong Province8.70.0444403See
ECUEcuador Andes Mixed Ancestry0.0443824See
MEXMexico Jalisco, Guadalajara city0.04401189See
BRABrazil Mato Grosso do Sul0.0440203See
ARGArgentina Cuyo Region8.60.0440420See
RUSRussia Samara Region0.04302500See
BRABrazil REDOME Tocantins0.043020692See
IRNIran0.043058See
MEXMexico Campeche Rural0.042647See
BRABrazil REDOME Mato Grosso do Sul0.042595667See
SAUSaudi Arabia pop 47.60.0421499See
ECUEcuador Coast Mixed Ancestry0.0420238See
MEXMexico Chihuahua, Ciudad Juarez0.0417106See
BRABrazil REDOME Ceara0.0413101217See
BRABrazil Rio Grande do Sul Mixed0.0410324See
BRABrazil Sao Paulo Bauru Mixed0.04103542See
MYSMalaysia pop 20.041062See
MEXMexico Jalisco Rural0.0410585See
MEXMexico Colima, Colima city0.041061See
BRABrazil REDOME Espirito Santo0.040188485See
BRABrazil REDOME Parana0.0401341639See
BRABrazil Rio Grande do Sul Black0.0400248See
VNMVietnam Hanoi0.040050See
THAThailand pop 20.0400124See
MEXMexico Baja California, Tijuana0.040025See
BRABrazil REDOME Rondonia0.039554396See
BRABrazil REDOME Sao Paulo0.0391800809See
TWNTaiwan Hakka pop 20.0390714See
TWNTaiwan Minnan pop 20.03907137See
HRVCroatia Gorski Kotar Region0.039063See
PRTPortugal Beja0.0390699See
MEXMexico Zacatecas Rural0.0390266See
IRNIran pop 40.0385855See
MEXMexico Durango Rural0.0382326See
MEXMexico Nuevo Leon, Monterrey city0.0376226See
BRABrazil REDOME Mato Grosso0.037534649See
BRABrazil REDOME Rio Grande do Sul0.0372241329See
MYSMalaysia pop 30.03701445See
IRNIran Royan Cord Blood Bank7.30.037015600See
ARGArgentina Buenos Aires pop 27.20.03701216See
RUSRussia Northwest pop 27.20.0370346See
BRABrazil REDOME Santa Catarina0.0365106673See
BRABrazil REDOME Alagoas0.036525349See
BRABrazil REDOME Paraiba0.036443868See
RUSRussia Northwest7.20.03601011See
BRABrazil Rio Grande do Norte Mestizo0.036012973See
MEXMexico Veracruz, Cordoba0.035756See
BRABrazil REDOME Rio Grande do Norte0.035646603See
MEXMexico Sonora, Hermosillo0.035499See
MEXMexico Baja Californa, Mexicali0.0350100See
FRAFrance Southeast6.90.0350130See
BRABrazil Rio Grande do Sul Caucasoid0.03504428See
BRABrazil REDOME Federal District0.035029549See
RUSRussia Northwest pop 37.00.0350100See
IRQIraq Erbil7.00.0350372See
RUSRussia Smolensk0.0350156See
PRTPortugal Bragança0.0350301See
PRTPortugal Faro0.03501242See
BRABrazil South East Cord Bllod0.034311409See
CHNChina Han6.70.0340314See
ZAFSouth Africa Limpopo Venda0.0340117See
PRTPortugal Evora0.0340737See
RUSRussia South Ural Russian6.80.0340207See
JAMJamaica0.0340132See
MEXMexico Sinaloa, Culiacán0.0340103See
MEXMexico Coahuila, Torreon0.0338396See
MEXMexico Guanajuato Rural0.0337162See
MEXMexico Chihuahua Chihuahua City0.0336119See
MEXMexico Morelos Rural0.033330See
CZECzech Republic pop 36.70.0330180See
BRABrazil Parana Caucasian6.60.03302775See
CHESwitzerland Lugano0.03251169See
RUSRussia Tatars0.0323355See
MEXMexico Guanajuato, Leon0.032178See
BRABrazil Sao Paulo Mixed6.30.0320239See
BRABrazil REDOME Goias0.031888574See
MEXMexico Tabasco Rural0.0317142See
CHESwitzerland Sion0.0316832See
MMRMyanmar Mon6.30.031364See
BRABrazil REDOME Minas Gerais0.0312211275See
BRABrazil REDOME Rio de Janeiro0.0311139322See
BRABrazil REDOME Pernambuco0.031092332See
SAUSaudi Arabia pop 20.0310383See
PRTPortugal Santarem0.03103865See
FRAFrance Marseille6.20.03071000See
CHESwitzerland Lausanne0.0305993See
BRABrazil REDOME Sergipe0.03057321See
MEXMexico Morelos, Cuernavaca0.030582See
FRAFrance Grenoble6.00.03011000See
BRABrazil Parana Oriental6.10.030033See
CHESwitzerland Zurich0.03004875See
CHESwitzerland Basel0.03001888See
ARMArmenia Syunik0.0300117See
BRABrazil Minas Gerais State Mixed5.80.03001000See
MEXMexico Zacatecas, Zacatecas city0.029884See
FRAFrance Lyon5.80.02914813See
ARMArmenia living in Karabakh0.0290445See
PRTAzores0.02901050See
BRABrazil REDOME Bahia0.028747399See
CHESwitzerland Aargau-Solothurn0.02871838See
MEXMexico Michoacan Rural0.0287348See
MEXMexico Zacatecas, Fresnillo0.0286103See
FRAFrance Bordeaux5.70.0285990See
PRTPortugal Portalegre0.02801254See
RUSRussia Kostroma Region0.0280126See
POLPoland Lodz0.0280103See
FRAFrance Rennes pop 45.60.02781000See
PRTPortugal Setubal0.02705268See
PRTPortugal Leiria0.02701847See
BRABrazil Parana Mulatto5.40.0270186See
FRAFrance Grenoble, Nantes and Rennes0.02706094See
USAUSA Southeast African American5.40.0270112See
TURTurkey pop 20.0270228See
MEXMexico Baja California, La Paz0.026775See
MEXMexico Yucatan Rural0.0261132See
PRTPortugal Center pop 20.0260562See
KURIraq Kurdistan Region5.30.0260209See
RUSRussia Arkhangelsk Pomor0.026063See
PRTPortugal Lisbon0.026017420See
CHNChina Shandong Province Linqu County5.00.0253139See
VENVenezuela Zulia Maracaibo Mixed0.025020See
VENVenezuela Zulia San Jose de Heras Mixed0.025020See
PRTPortugal Viana do Castelo0.0250706See
PRTPortugal Braga0.02501971See
CHESwitzerland Bern0.02493545See
MEXMexico Hidalgo, Pachuca0.024441See
DEUGermany4.80.024311407See
RUSRussia South Ural Bashkir4.80.0240146See
PRTPortugal Vila Real0.02401167See
PRTPortugal Porto0.02407937See
PRTPortugal Coimbra0.02405057See
CHNChina Shaanxi Province Han0.024010000See
PRTPortugal South pop 20.02401021See
TWNTaiwan Chinese immigrants from Middle China0.0240211See
ITAItaly North pop 24.60.02402054See
CHESwitzerland Geneva pop 20.02371267See
TWNTaiwan Aborigine0.0230111See
PRTPortugal Castelo Branco0.0230327See
CHESwitzerland Graubunden0.0229759See
MEXMexico Guanajuato, Guanajuato city0.022722See
ITAItaly Central0.0220380See
CHNChina Shandong Province4.30.02207418See
RUSRussia Mari0.0220202See
BRABrazil Parana Cafuzo4.40.0220319See
RUSRussia, South Ural, Chelyabinsk region, Nagaybaks4.50.0220112See
CHESwitzerland St Gallen0.02172113See
ARMArmenia living in USA0.0210233See
CUBCuba Mixed pop 20.0210189See
MEXMexico Chihuahua Rural0.0209236See
MEXMexico Quintana Roo, Cancun0.020848See
MEXMexico Yucatan, Merida0.0205192See
MEXMexico Quintana Roo Rural0.020050See
MEXMexico Baja California Rural0.020050See
ISRIsrael Jews pop 23.90.020023000See
BFABurkina Faso Mossi0.020053See
TTOTrinidad South Asian0.020087See
PAKPakistan Mixed Pathan0.0200100See
PRTAzores Terceira Island0.0200130See
GBRUnited Kingdom pop 20.0200101See
MEXMexico Michoacan, Morelia0.0199150See
RUSRussia North Ossetian3.90.0197127See
ESPSpain Malaga3.80.0191160See
RUSRussia Arkhangelsk0.019081See
ARMArmenia Yerevan0.0190445See
ARMArmenia Ghegharkunik0.0190242See
BRABrazil Parana Afro Brazilian3.90.019077See
PRTPortugal Guarda0.0190797See
PRTPortugal Viseu0.01902915See
GBRUnited Kingdom East0.0189163See
MEXMexico Chiapas, Tuxtla Gutierrez0.018952See
MMRMyanmar Shan3.70.018554See
CHNChina Shanghai0.018026266See
MEXMexico Sinaloa Mestizo0.018056See
MEXMexico Sonora Rural0.0178197See
ESPSpain Valencia3.50.0176577See
MEXMexico Sonora, Ciudad Obregón0.0175143See
RUSRussia Vologda0.0170121See
GEOGeorgia Kurds0.017030See
PRTPortugal Aveiro0.01705933See
PAKPakistan Karachi Parsi0.017091See
MEXMexico Jalisco, Tlajomulco0.016730See
BRABrazil South Ribeirao Preto0.0160184See
PRTPortugal North pop 20.01551801See
ESPSpain Northwest3.00.01511818See
ESPSpain North3.00.0151156See
ENGEngland Lancaster3.00.0151545See
BRABrazil Southeast Campinas Mixed3.00.015199See
GBRUnited Kingdom Central0.0150135See
INDIndia Andhra Pradesh Sunni0.80.0150100See
CHNChina Jiangsu Province0.015020248See
PAKPakistan Mixed Sindhi0.0150101See
SWESweden pop 42.90.0150966See
ARMArmenia Lori0.0150102See
MEXMexico Mexico City West0.014733See
MEXMexico Jalisco, Tonala0.014335See
MEXMexico Coahuila Rural0.0138216See
CZECzech Republic Kurd2.70.013574See
ESPSpain Granada0.0130280See
TWNTaiwan Chinese immigrants from North China0.0130152See
GBRUnited Kingdom Orkney0.012388See
MEXMexico Hidalgo Rural0.012381See
ENGEngland2.40.0120537See
MEXMexico Queretaro Rural0.011643See
MEXMexico Veracruz, Poza Rica0.011145See
GBRUnited Kingdom renal patients2.10.01107007See
KORSouth Korea pop 80.01107096See
FINFinland0.011091See
PRTMadeira pop 30.0110538See
AUSAustralia West Caucasian2.10.0110891See
MEXMexico Sinaloa Rural0.0109183See
MMRMyanmar Bamar2.20.010947See
INDIndia North Gujarat1.80.0105338See
MMRMyanmar Rakhine2.10.010448See
TTOTrinidad African0.010067See
BGDBangladesh Dhaka Bangalee0.0100141See
VENVenezuela Valencia and Maracaibo Caracus Mixed0.010096See
ARMArmenia living in Lebanon0.0100368See
MEXMexico Guadalajara Mestizo0.009054See
RUSRussia Nenet Mixed0.009055See
LKASri Lanka Colombo Sinhalese0.0090101See
TZATanzania Dodoma Kongwa0.0090212See
ENGEngland Sheffield1.60.00804755See
IRLIreland Wexford1.50.0080200See
ENGEngland Newcastle1.60.00802739See
JORJordan0.008015141See
ARGArgentina La Plata2.00.0080100See
SWESweden pop 50.00801569See
INDIndia Bikaner Raikas1.50.0080143See
ENGEngland North West Mixed pop 21.60.0079379See
SWESweden Stockholm1.30.00701347See
ENGEngland Manchester1.20.00601640See
WALWales pop 21.30.006039979See
ENGEngland Leeds1.20.00605024See
ARMArmenia living in Iran0.006085See
RUSRussia Murmansk Saomi Mixed0.006070See
INDIndia North pop 30.0051587See
INDIndia Uttar Pradesh0.0050202See
WALWales1.10.00501798See
ENGEngland Liverpool0.90.00451343See
NORNorway ethnic Norwegians0.80.00394510See
IRLIreland South pop 20.003217624See
GBRUnited Kingdom South West0.0031163See
FRAFrance West Breton0.0030150See
JPNJapan pop 100.0030332See
IRLIreland Donegal0.50.0030200See
MOZMozambique0.0020202See
GBRUnited Kingdom North0.0015330See
MARMorocco pop 20.0000110See
BFABurkina Faso Rimaibe0.000047See
ESPSpain Gipuzkoa Basque0.0000100See
ESPSpain Catalonia Girona0.000088See
BFABurkina Faso Fulani0.000049See
INDIndia Andhra Pradesh Brahmin0.00.000098See
PAKPakistan Kalash0.000069See
ARGArgentina Salta Wichi pop 20.00.000019See
PAKPakistan Burusho0.000092See
INDIndia Bikaner Non-Raikas0.00.0000127See
MEXMexico Campeche, Campeche city0.000034See

Frequency data at lower resolution for this allele can be found in links below


Allele  Number of Populations 

Notes:

* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


   

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations.
Gonzalez-Galarza FF, Takeshita LY, Santos EJ, Kempson F, Maia MH, Silva AL, Silva AL, Ghattaoraya GS, Alfirevic A, Jones AR and Middleton D Nucleic Acid Research 2015, 39, 28, D784-8.
Liverpool, U.K.

support@allelefrequencies.net


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