Allele Frequencies in World Populations

HLA Database » Allele Report

The list below shows all populations in AFND that contains the allele. If an allele has an entry with a lower resolution this will be shown at the end.



Allele reported 296 time(s) and present in 201 population(s).

Population Phenotype
Frequency (%)
Distribution² Haplotype³
COLColombia West Cauca0.200020See
GHAGhana Accre Asutuare Akan0.1720429See
KENKenya, Nyanza Province, Luo tribe22.00.1100100See
STPSao Tome Island Angolar0.109032See
COLColombia North Chimila Amerindians0.095747See
SAUSaudi Arabia17.60.092218See
ZAFSouth Africa Limpopo Venda0.0900117See
IRNIran Baloch0.0850100See
COLColombia San Basilio de Palenque0.083042See
COLColombia Barranquilla0.0720188See
COLColombia Providencia Island African0.067030See
USAUSA NMDP Caribean Black0.066433328See
ZWEZimbabwe Harare Shona0.0660230See
USAUSA African American pop 40.06532411See
USAUSA NMDP African American pop 20.0631416581See
USAUSA African American pop 70.0620193See
USAUSA NMDP African0.060428557See
STPSao Tome Island Forro0.053066See
COLColombia Northwest Choco0.050020See
TZATanzania Maasai9.50.0489336See
USAUSA Colorado Univ Cord Blood Bank African American0.0470261See
USAUSA NMDP Caribean Indian0.043014339See
ZAFSouth Africa Worcester8.00.0410159See
RWARwanda Kigali Hutu and Tutsi0.0410281See
USAUSA African American Bethesda7.00.0350187See
USAUSA NMDP Caribean Hispanic0.0335115374See
CODCongo Kinshasa Bantu6.70.033090See
SENSenegal Dakar6.70.0330112See
GAZGaza Palestinians0.0330165See
GMBGambia pop 36.00.0317939See
MEXMexico Tamaulipas Rural0.0317125See
MEXMexico Baja California, La Paz0.026775See
TUNTunisia pop 30.0240104See
CUBCuba Mixed0.023078See
CODCongo Kinshasa expatriates living in Belgium4.60.023075See
MEXMexico Veracruz, Poza Rica0.022245See
BRABrazil Mixed0.0200108See
MEXMexico Baja California Rural0.020050See
AREUnited Arab Emirates Abu Dhabi0.019252See
AREUnited Arab Emirates Pop 10.0180570See
MEXMexico Tabasco Rural0.0176142See
MEXMexico San Luis Potosi, San Luis Potosi city0.016730See
COLColombia Bogotá Cord Blood3.20.01641463See
MEXMexico Guanajuato Rural0.0153162See
DZAAlgeria pop 23.00.0151106See
BRABrazil North East Mixed0.0150205See
INDIndia Northeast Rastogi0.0150196See
BRABrazil Mato Grosso do Sul0.0150203See
MEXMexico Zacatecas Rural0.0149266See
PERPeru Titikaka Lake Uros0.0140105See
ESPSpain Tenerife Island0.014083See
PERPeru Titikaka Lake Uro0.0140105See
MEXMexico Nuevo Leon Rural0.0136439See
ECUEcuadorean Amerindians0.013375See
GNQEquatorial Guinea Bioko Island Bubi0.0130100See
ISRIsrael Ashkenazi Jews0.013080See
MEXMexico Jalisco, Tlaquepaque0.012839See
USAUSA San Diego2.00.0120496See
BRABrazil Southeast Mixed Race2.40.012042See
AREUnited Arab Emirates pop 22.10.0110373See
MEXMexico Quintana Roo, Cancun0.010448See
USAUSA NMDP Hispanic South or Central American0.0103146714See
MEXMexico Sonora, Hermosillo0.010199See
MEXMexico Quintana Roo Rural0.010050See
SAUSaudi Arabia Guraiat and Hail1.50.0100213See
IRNIran Azeri0.0100100See
PRTPortugal Center0.010050See
BRABrazil Southeast Caucasian1.90.0100103See
DZAAlgeria Oran0.0100100See
MEXMexico Guanajuato and Jalisco Mestizo2.00.0100101See
MARMorocco Souss Region0.010098See
ISRIsrael Arab pop 20.010012301See
COLColombia North Wiwa El Encanto0.009652See
MEXMexico Chihuahua, Ciudad Juarez0.0093106See
SAUSaudi Arabia pop 6 (G)0.009028927See
MEXMexico Veracruz, Coatzacoalcos0.008955See
MEXMexico Jalisco, Zapopan0.0089168See
MEXMexico Jalisco, Guadalajara city0.00881189See
ECUEcuador Coast Mixed Ancestry0.0084238See
IRNIran pop 20.0083120See
MEXMexico Colima, Colima city0.008261See
USAUSA Hispanic pop 20.00801999See
MEXMexico Nayarit Rural0.007864See
CHLChile Mapuche0.007766See
MEXMexico Sonora Rural0.0076197See
NICNicaragua Managua1.50.0075339See
MEXMexico Michoacan Rural0.0072348See
BRABrazil Paraná Caucasian1.20.0070641See
USAUSA Philadelphia Caucasian1.40.0070141See
MEXMexico Coahuila, Saltillo0.006872See
MEXMexico Guanajuato, Leon0.006478See
MEXMexico Chihuahua Rural0.0063236See
MEXMexico Tabasco, Villahermosa0.006182See
MEXMexico Zacatecas, Zacatecas city0.006084See
MEXMexico Veracruz Xalapa1.20.006084See
TUNTunisia Matmata Berber0.006081See
BRABrazil Guarani Nandeva0.006086See
MEXMexico Aguascalientes state0.005395See
MEXMexico Nayarit, Tepic0.005297See
IRNIran Tabriz Azeris0.005297See
TUNTunisia Gabes0.005295See
USAUSA NMDP Mexican or Chicano0.0050261235See
MEXMexico Baja Californa, Mexicali0.0050100See
USAUSA South Texas Hispanic0.0050194See
CZECzech Republic0.0050106See
TUNTunisia Gabes Arab0.005096See
ISRIsrael Moroccan Jews0.0050113See
IRNIran Kurd0.0050100See
COLColombia Antioquia Paisa0.0050100See
SDNSudan Mixed1.00.0050200See
MEXMexico Puebla Mestizo0.005099See
ZAFSouth Africa Caucasians0.0050102See
MEXMexico Zacatecas, Fresnillo0.0048103See
MEXMexico Chihuahua Chihuahua City0.0042119See
MEXMexico Tlaxcala Rural0.0042830See
USAUSA NMDP American Indian South or Central America0.00405926See
USAUSA Mexican American Mestizo pop 30.0040116See
ISRIsrael Ashkenazi Jews pop 20.0040132See
CHNChina Wuhan0.80.0040121See
USAUSA Colorado Univ Cord Blood Bank Hispanic0.00401058See
ESPSpain Granada0.0040280See
ESPSpain Murcia0.0040173See
ECUEcuador Mixed Ancestry0.00381173See
MEXMexico Sonora, Ciudad Obregón0.0035143See
MEXMexico Jalisco Rural0.0034585See
MEXMexico Michoacan, Morelia0.0033150See
MEXMexico Oaxaca, Oaxaca city0.0033151See
MEXMexico Durango, Durango city0.0032153See
ECUEcuador Andes Mixed Ancestry0.0030824See
USAUSA Caucasian Bethesda0.60.0030307See
LBNLebanon pop 20.0030191See
INDIndia Northeast Kayastha0.0030190See
MEXMexico Veracruz, Veracruz city0.0029171See
MEXMexico Veracruz Rural0.0028539See
MEXMexico Coahuila, Torreon0.0025396See
USAUSA NMDP North American Amerindian0.002135791See
MEXMexico Mexico City Mestizo pop 20.0021234See
KORSouth Korea pop 10.0020324See
MEXMexico Puebla, Puebla city0.00181994See
CHLChile Santiago0.0016920See
USAUSA NMDP Middle Eastern or North Coast of Africa0.001670890See
ISRIsrael Druze0.00155914See
MEXMexico Durango Rural0.0015326See
MEXMexico Mexico City Tlalpan0.30.0015330See
DEUGermany DKMS - Italy minority0.00151159See
ESPSpain Valencia0.30.0015577See
DEUGermany DKMS - United Kingdom minority0.00141043See
DEUGermany DKMS - Portugal minority0.00131176See
MYSMalaysia Peninsular Malay0.20.0011951See
USAUSA NMDP Hawaiian or other Pacific Islander0.001111499See
MEXMexico Oaxaca Rural0.0010485See
ITAItaly pop 50.0010975See
USAUSA NMDP Alaska Native or Aleut0.00101376See
USAUSA Caucasian pop 40.00101070See
USAUSA Eastern European0.0010558See
USAUSA Colorado Univ Cord Blood Bank Caucasian0.00103830See
ITAItaly Central0.0010380See
INDIndia Tamil Nadu0.00082492See
ISRIsrael YemenJews0.000715542See
DEUGermany DKMS - France minority0.00071406See
ISRIsrael USA Jews0.00076058See
MEXMexico Puebla Rural0.0006833See
ESPSpain (Catalunya, Navarra, Extremadura, Aaragón, Cantabria,0.10.00064335See
ESPSpain Barcelona0.10.0005941See
DEUGermany DKMS - Bosnia and Herzegovina minority0.00051028See
DEUGermany DKMS - Spain minority0.00051107See
DEUGermany DKMS - Turkey minority0.00044856See
USAUSA NMDP European Caucasian0.00031242890See
DEUGermany DKMS - Austria minority0.00031698See
ISRIsrael Ethiopia Jews0.00035928See
ISRIsrael Iran Jews0.00028153See
ISRIsrael Argentina Jews0.00024307See
DEUGermany DKMS - Greece minority0.00031894See
USAUSA NMDP Filipino0.000250614See
DEUGermany DKMS - German donors0.00023456066See
USAUSA NMDP Southeast Asian0.000127978See
ISRIsrael Morocco Jews0.000136718See
USAUSA NMDP Vietnamese0.000143540See
DEUGermany pop 80.000139689See
POLPoland DKMS0.000220653See
DEUGermany pop 60.00028862See
INDIndia West UCBB0.00.00015829See
USAUSA NMDP South Asian Indian0.0001185391See
USAUSA NMDP Japanese0.000124582See
HKGHong Kong Chinese BMDR0.00017595See
ISRIsrael Tunisia Jews0.00019070See
ISRIsrael Iraq Jews0.000013270See
ISRIsrael Poland Jews0.000013871See
USAUSA NMDP Chinese0.000099672See
USAUSA NMDP Korean0.000077584See
ISRIsrael USSR Jews0.000045681See
BRABrazil Vale do Ribeira Quilombos0.10.0000144See
NLDNetherlands Leiden0.00001305See
ECUEcuador Amazonia Mixed Ancestry0.000039See
MEXMexico Morelos, Cuernavaca0.000082See
MEXMexico Mexico City West0.000033See
MEXMexico Yucatan, Merida0.0000192See
MEXMexico Campeche, Campeche city0.000034See
MEXMexico Chiapas, Tuxtla Gutierrez0.000052See
MEXMexico Tlaxcala, Tlaxcala city0.0000181See
MEXMexico Mexico City South0.000052See
MEXMexico Mexico City North0.0000751See
MEXMexico Mexico City East0.000079See
MEXMexico Mexico City Center0.0000152See
MEXMexico Hidalgo, Pachuca0.000041See
MEXMexico Veracruz, Xalapa0.0000187See
MEXMexico Guerrero state0.0000144See
MEXMexico Tamaulipas, Ciudad Victoria0.000023See
MEXMexico Queretaro, Queretaro city0.000045See
MEXMexico Veracruz, Cordoba0.000056See
MEXMexico Veracruz, Orizaba0.000060See
MEXMexico Baja California, Tijuana0.000025See
MEXMexico Hidalgo Rural0.000081See
MEXMexico Mexico City Metropolitan Area Rural0.0000150See
MEXMexico Queretaro Rural0.000043See
MEXMexico San Luis Potosi Rural0.000087See
MEXMexico Morelos Rural0.000030See
MEXMexico Chiapas Rural0.0000121See
MEXMexico Campeche Rural0.000047See
MEXMexico Yucatan Rural0.0000132See
MEXMexico Coahuila Rural0.0000216See
MEXMexico Sinaloa Rural0.0000183See
MEXMexico Colima Rural0.000043See
MEXMexico Sinaloa, Culiacán0.0000103See
MEXMexico Jalisco, Tlajomulco0.000030See
MEXMexico Jalisco, Tonala0.000035See
MEXMexico Nuevo Leon, Monterrey city0.0000226See
MEXMexico Guanajuato, Guanajuato city0.000022See
MEXMexico Mexico City Mestizo0.0000121See
MEXMexico Sinaloa Mestizo0.000056See
FRAFrance Rennes pop 30.0000200See
ARGArgentina Rio Negro Mapuche0.000034See
ARGArgentina Chubut Tehuelche0.000023See
ARGArgentina Salta Wichi0.000024See
PRYParaguay Lengua0.000017See
INDIndia Northeast Mathur0.0000155See
INDIndia Northeast Vaish0.0000198See
INDIndia Northeast Shia0.0000190See
INDIndia Northeast Sunni0.0000188See
INDIndia Northeast Lachung0.000058See
INDIndia Northeast Mech0.000063See
INDIndia Northeast Rajbanshi0.000098See
FRAFrance Rennes0.0000200See
TUNTunisia Jerba Berber0.000055See
USAUSA Asian pop 20.00001772See
PRTPortugal South0.000049See
CANCanada British Columbia Athabaskan0.000062See
CANCanada British Columbia Penutian0.000026See
PRTPortugal North0.000046See
ITAItaly Rome0.00.0000100See
ITAItaly North pop 30.00.000097See
ITAItaly Bergamo0.00.0000101See
USAUSA Caucasian0.00.000061655See
USAUSA San Antonio Caucasian0.0000222See
KORSouth Korea pop 20.00.0000207See
USAUSA Alaska Yupik0.0000252See
BRABrazil Kaingang0.0000235See
USAUSA Colorado Univ Cord Blood Bank Asian0.0000100See
MARMorocco Nador Metalsa0.000099See
MARMorocco Settat Chaouya0.000098See
BRABrazil Guarani M bya0.000093See
USAUSA Caucasian Houston0.00.0000194See
USAUSA Caucasian Pittsburgh0.00.0000177See
CAFCentral African Republic Aka Pygmy0.00.000093See
FRAFrance West0.00.0000100See
COLColombia Bogota and Medellin Mestizo0.000065See
COKCook Islands Rarotonga0.000078See
WSMWestern Samoa and Tokelau0.000051See
IDNIndonesia Java Yogyakarta Region0.000062See
PRYParaguay Aché0.000087See
PERPeru Quechua0.000044See
BRABrazil East Amazon0.000041See
CHNChina Urumqi Uyghur0.00.000057See
ENGEngland pop 60.00.0000177See
ISRIsrael Libyan Jews0.0000119See
ISRIsrael Iranian Jews0.0000101See
ISRIsrael Ethiopian Jews0.0000122See
ISRIsrael Yemenite Jews0.000076See
ISRIsrael Arab0.0000109See
MEXMexico Highlands Mestizos0.00.0000160See
MEXMexico Nuevo Leon Mestizo0.00.000040See

Frequency data at lower resolution for this allele can be found in links below

Allele  Number of Populations 


* Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format.
   Important: This field has been expanded to four decimals to better represent frequencies of large datasets (e.g. where sample size > 1000 individuals)
* Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n).
* Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions.

¹ IMGT/HLA Database - For more details of the allele.
² Distribution - Graphical distribution of the allele.
³ Haplotype Association - Find HLA haplotypes with this allele.
ª Notes - See notes for ambiguous combinations of alleles.


Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.

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