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HLA » Estimation of Global Allele Frequencies
About this tool
This search has been designed to provide an insight of the overall HLA frequencies based on the total of populations submitted to the AFND.
Users may find this tool useful to visualise global frequencies by geographic region, country, ethnic origin, or any other classification available.
It is important to highlight that HLA allele frequencies may vary considerably between two populations in a given
country, geographic region, etc., thus, this tool should be used only as an initial approach to investigate global frequencies of alleles. The Allele Frequency Search (AFS)
included in the homepage's menu provides a more detailed description of the frequencies by population.
| Allele | Times reported ¹ |
Allele Counts ² | Sample Size (2n) ³ |
Overall Allele Frequency |
|---|---|---|---|---|
| A*11:88 | 8 | 41 | 33,764 | 0.00122 |
| A*23:27 | 8 | 13 | 271,436 | 0.00005 |
| A*24:109 | 8 | 43 | 2,128,138 | 0.00002 |
| A*24:39 | 8 | 14 | 6,916,734 | 0.00000 |
| A*24:43 | 8 | 165 | 9,480,904 | 0.00002 |
| A*24:72 | 8 | 157 | 9,820,964 | 0.00002 |
| A*32:21 | 8 | 5 | 475,298 | 0.00001 |
| A*74:14N | 8 | 3 | 7,382,786 | 0.00000 |
| A*01:26 | 7 | 27 | 9,503,530 | 0.00000 |
| A*01:43 | 7 | 29 | 7,327,754 | 0.00000 |
| A*02:101 | 7 | 4 | 9,736,592 | 0.00000 |
| A*02:121 | 7 | 12 | 9,573,816 | 0.00000 |
| A*02:122 | 7 | 17 | 3,903,038 | 0.00000 |
| A*02:133 | 7 | 45 | 7,024,538 | 0.00001 |
| A*02:135 | 7 | 30 | 6,947,168 | 0.00000 |
| A*02:152 | 7 | 6 | 2,810,052 | 0.00000 |
| A*02:156 | 7 | 23 | 9,432,920 | 0.00000 |
| A*02:614 | 7 | 22 | 81,630 | 0.00027 |
| A*02:66 | 7 | 7 | 30,580 | 0.00023 |
| A*02:76 | 7 | 1 | 6,938,744 | 0.00000 |
| A*02:77 | 7 | 4 | 2,515,688 | 0.00000 |
| A*03:15 | 7 | 63 | 9,401,526 | 0.00001 |
| A*11:22 | 7 | 2 | 461,476 | 0.00000 |
| A*11:24 | 7 | 4 | 7,416,212 | 0.00000 |
| A*11:326 | 7 | 32 | 6,946,702 | 0.00000 |
| A*11:44 | 7 | 17 | 757,930 | 0.00002 |
| A*23:15 | 7 | 47 | 8,240,422 | 0.00001 |
| A*24:46 | 7 | 7 | 2,669,690 | 0.00000 |
| A*24:57 | 7 | 16 | 9,428,040 | 0.00000 |
| A*24:58 | 7 | 204 | 9,413,082 | 0.00002 |
| A*25:06 | 7 | 15 | 2,918,770 | 0.00001 |
| A*25:11 | 7 | 4 | 3,011,262 | 0.00000 |
| A*30:25 | 7 | 6 | 566,686 | 0.00001 |
| A*32:09 | 7 | 2 | 3,322,556 | 0.00000 |
| A*34:06 | 7 | 1 | 7,057,526 | 0.00000 |
| A*68:29 | 7 | 3 | 857,902 | 0.00000 |
| A*68:31 | 7 | 25 | 7,869,074 | 0.00000 |
| A*68:35 | 7 | 141 | 10,049,756 | 0.00001 |
| A*01:100 | 6 | 18 | 6,945,106 | 0.00000 |
| A*01:24 | 6 | 6 | 3,535,232 | 0.00000 |
| A*01:274 | 6 | 23 | 34,312 | 0.00067 |
| A*01:28 | 6 | 5 | 166,300 | 0.00003 |
| A*02:105 | 6 | 2 | 7,832,064 | 0.00000 |
| A*02:114 | 6 | 7 | 10,024,416 | 0.00000 |
| A*02:119 | 6 | 23 | 9,923,398 | 0.00000 |
| A*02:138 | 6 | 11 | 9,437,210 | 0.00000 |
| A*02:149 | 6 | 11 | 9,552,696 | 0.00000 |
| A*02:160 | 6 | 30 | 7,896,300 | 0.00000 |
| A*02:162 | 6 | 8 | 3,469,948 | 0.00000 |
| A*02:165 | 6 | 2 | 7,870,346 | 0.00000 |
Notes:
* Only four digit alleles were computed in this analysis.
¹ Times reported. Number of confirmations of the allele in the AFND.
² Allele counts. Number of copies of the allele submitted to the AFND based on frequencies.
³ Sample size. Number of copies based on population's sample size (2n).
Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools
Gonzalez-Galarza FF, McCabe A, Santos EJ, Jones J, Takeshita LY, Ortega-Rivera ND, Del Cid-Pavon GM, Ramsbottom K, Ghattaoraya GS, Alfirevic A, Middleton D and Jones AR Nucleic Acid Research 2020, 48:D783-8.
Liverpool, U.K.
support@allelefrequencies.net